TGFB1 and psoriasis: In a systematic review by Khalilzadeh et al. (2019) on the therapeutic effects of thermal water, has been observed as saline waters (sodium-chloride rich) presenting a high content of minerals, can reduce the enzyme leukocyte esterase, involved in psoriasis, the transforming growth factor-β (TGF-β), increased in psoriatic patients, the Langerhans cells of the epidermis and skin infections trough the removal of bacteria that contribute to seborrheic dermatitis and other dermatological diseases.