Similar to EwS tumors (Figure 3F), GSEA analysis of HSAT2,3-high versus -low PCa tumors revealed evidence of cell cycle dysregulation and genotoxic stress, as manifested by significant upregulation of E2F, MYC, G2/M checkpoint, mitotic spindle, and DNA damage repair networks (FDR < 0.05; Figure 5I), while downregulated pathways did not reach statistical significance (Figure 5J). The gene discussed is MYC; the disease is posterior cortical atrophy.