Both EWS:FLI1 and EWS:ERG in EwS, and aberrantly expressed ERG in PCa can bind to GGAA repeats in the promoters and enhancers of coding genes and within microsatellites, causing widespread chromatin remodeling and transcriptional rewiring (5, 6, 9–13). This evidence concerns the gene FLI1 and posterior cortical atrophy.