To determine the clinical significance of the CD73 proteolytic regulation in TNBC’s immune response and prognosis, CIBERSORT analysis (Supplemental Figure 15, A and B) showed breast tumors with heightened TRIM21 expression were characterized by an increased CD8+ T cell population and showed an increase in lymphocyte infiltration accompanied by an IFN-γ signature. This evidence concerns the gene IFNG and breast neoplasm.