To evaluate the importance of the physical interaction between OTUD4 and CD73 for tumor growth, we overexpressed both OTUD4 and CD73WT (OTUD4 OE + CD73WT) or OTUD4 and CD73V300P/I301Q with mutated interaction sites (OTUD4 OE + CD73V300P/I301Q) in EO771 cells. This evidence concerns the gene NT5E and neoplasm.