To determine the clinical significance of the CD73 proteolytic regulation in TNBC’s immune response and prognosis, CIBERSORT analysis (Supplemental Figure 15, A and B) showed breast tumors with heightened TRIM21 expression were characterized by an increased CD8+ T cell population and showed an increase in lymphocyte infiltration accompanied by an IFN-γ signature. The gene discussed is NT5E; the disease is breast neoplasm.