Following the cessation of glucose supply through the umbilical cord after delivery, blood glucose levels drop to a nadir at 30 to 90 minutes postnatally, and then gradually rise to adult levels by the fourth day of life.3,4,5,6 In children with risk factors, hypoglycemia may be more severe and prolonged, or may occur later in the first days of life, eg, in case of lower glycogen reserves, increased glucose consumption, or increased insulin secretion.7 Therefore, neonates with risk factors usually undergo blood glucose screening to identify hypoglycemia early and treat it appropriately. The gene discussed is INS; the disease is Hypoglycemia.