NLRP3 and cryopyrin-associated periodic syndrome: Cryopyrinopathies (cryopyrin-associated periodic syndrome, CAPS), now referred to as NLRP3-associated autoinflammatory diseases (NLRP3-AID), were historically described as three dominant clinical entities: familial cold urticaria (FCAS), Muckle–Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disease (NOMID, also referred to as chronic infantile neurological cutaneous and joint syndrome, CINCA) (Hoffman et al., 2001; Booshehri and Hoffman, 2019).