ITIH3 and clear cell renal carcinoma: As an example, ITIH3, which was identified among the protein features for the plasma or serum-based classifier and highly abundant in cancer samples, was reported to be more highly expressed in the plasma of gastric cancer samples compared to the control (Chong et al., 2010) and increased with tumor staging of clear cell renal cell carcinoma patients (Chang et al., 2021).