For example, apolipoprotein C1 (APOC1), which was ranked as the top protein, is significantly decreased in samples of cancer patients (Figure 4—figure supplement 1B) and has been previously reported to be down-regulated in the non-small lung cancer, colorectal cancer, papillary thyroid carcinoma, and pediatric nephroblastoma (Zhang et al., 2011; Jin et al., 2019; Engwegen et al., 2008; Fan et al., 2009). The gene discussed is APOC1; the disease is thyroid gland papillary carcinoma.