Dravet syndrome model mice with a clinically relevant SCN1A mutation (Scn1a-A1783V knock-in mice) (Ricobaraza et al., 2019) and mutant Snap25 (S187A) knock-in mice (Kataoka et al., 2011) developed convulsive seizures. This evidence concerns the gene SNAP25 and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.