The high pH/low lactate group and moderate-high pH/moderate-low lactate group included mouse models of ASD or developmental delay, such as Shank2 KO, Fmr1 KO, BTBR, Stxbp1 KO, Dyrk1 KO, Auts2 KO, and 15q dup mice (Supplementary file 1, Figure 2—figure supplement 5). This evidence concerns the gene DYRK1A and Global developmental delay.