While early studies on the role of RANKL signaling in FD facilitated this promising therapeutic approach, little exploration has been done to find additional cytokines and factors secreted by FD BMSCs that may affect osteoclastic-osteoprogenitor crosstalk, as well as other important features of the FD pathogenesis, such as fibrous tissue deposition and remodeling, angiogenesis, and nociception. Here, TNFSF11 is linked to Fabry disease.