In addition to these cytokines, we measured other factors involved in the FD microenvironment, such as the proteases MMP2 and FAPα, the WNT modulator Dkk1, the growth factors VEGF and β-NGF and modulators of osteoclastogenesis previously shown to be produced by osteogenic cells (EPHD4, FASL and SEMA3A). The gene discussed is FAP; the disease is Fabry disease.