AQP1 and Parkinson disease: To delineate neuronal changes specifically linked to PD, we investigated the differences between HT707 TH-neo and HT708 TH-neo. A network of molecular chaperones, including HSPA6 of the heat shock 70 kDa protein family and its co-chaperone BAG3, were upregulated in HT708 TH-neo, potentially suggesting disruptions in protein homeostasis due to the PD genetic background (Fig. 6e).