VEGFC and age-related macular degeneration: Nakao et al. also showed that VEGF-C expression was upregulated in AMD but did not result in typical lymphangiogenesis (Nakao et al., 2013); similar to what was observed in choroidal melanoma mentioned above, Cabral proposed that this result may involve the interaction between VEGF-A and VEGF-C (Cabral et al., 2018).