To further strengthen this observation and given that apoptosis is one of the major mechanisms by which hosts evade viral infections, including HPV (Shimada et al., 2020; Gusho and Laimins, 2022), we assessed the ability of BB-Cl-A to drive cell-death pathways in CaSki cells by dual staining with annexin V and PI. The gene discussed is ANXA5; the disease is viral infectious disease.