The accumulation ratios of Rmax and AUEC0-24 h for plasma active GLP-1 in 50 mg cetagliptin, 100 mg cetagliptin, and sitagliptin groups were about 1.5 in patients with T2DM, and about 1.0 in healthy subjects, indicating that patients with T2DM were more sensitive to drugs. The gene discussed is GLP1R; the disease is type 2 diabetes mellitus.