In hepatocellular carcinoma (HCC), a novel prognostic signature composed of 6 key lactate metabolism-related genes (FKTN, PDSS1, PET117, PUS1, RARS1, and RNASEH1) was developed to predict the survival and tumor microenvironment of HCC patients (44). The gene discussed is RNASEH1; the disease is hepatocellular carcinoma.