For SNPs shared by WHRadjBMI and GSD, rs55666908 was a novel pleiotropic SNP that maps to JMJD1C. JMJD1C is a candidate histone demethylase and is thought to be a coactivator for key transcription factors, and its involvement in GSD and central obesity has rarely been studied. This evidence concerns the gene JMJD1C and disorder of glycogen metabolism.