TGFB1 and cancer: The extent of platelet activation influences several effector factors, such as Vascular Endothelial Growth Factor (VEGF), Platelet-derived growth factor (PDGF), and transforming growth factor-β (TGF-β), which influence vascular maturation in the tumor microenvironment and mediate cancer cell invasion (61), which are associated with the survival rate of BC patients.