The HMGB1/RAGE axis promotes tumor cell proliferation in various malignant tumors, including hepatocellular carcinoma, non-small cell lung cancer, cervical cancer, glioma, clear cell renal cell carcinoma, pancreatic cancer, breast cancer, nasopharyngeal carcinoma, colorectal cancer, and gastric cancer. The gene discussed is HMGB1; the disease is clear cell renal carcinoma.