In addition, Dy et al. (2019) found that MTMR3/MTMR4 regulated interferon gene stimulating factor (STING) trafficking by regulating ptdins3p production, suggesting that MTMR3/MTMR4 may be a potential therapeutic target in the process of myocardial fibrosis, macrophage infiltration and cardiac inflammatory response in patients with diabetes and obesity mediated by STING signaling, which needs to be further experimentally verified (43). The gene discussed is MTMR3; the disease is obesity due to melanocortin 4 receptor deficiency.