MTM1 and Cholestatic liver disease: The most recent report was that in 2023, Ka et al. described in a model of zebrafish that loss-of-function mutations in MTM1 lead to severe cholestatic liver disease, while previous studies have reported that there may be increased cardiovascular risk factors in children with cholestatic disease, suggesting that MTM1 may be involved in the occurrence and development of cardiovascular events (35).