Based on the expression pattern of PPARs across pan-cancer in TGCA database, the current study analyzed the signaling pathways and biological functions of the three PPAR genes (PPARA, PPARD and PPARG) to further explore the relationship between the three genes and the prognosis, clinical features, immune microenvironment and traditional chemotherapy drugs in STAD. This evidence concerns the gene PPARA and gastric adenocarcinoma.