PRL increased the Th1 lymphocytes-induced synthesis of interferon gamma (IFN-γ) and IL-2, and activated Th2 lymphocytes-induced production of autoantibody, therefore of worthy interest was the association between hyperprolactinemia and levels of cytokines and specific/nonspecific antibodies in autoimmune diseases (69). Here, PRL is linked to hyperprolactinemia.