MAPK8 and perinatal asphyxia: 1.Induce inflammation via cytokine expression and JNK/ERK phosphorylation.2.Limits autophagosome-lysosome fusion, reduces autophagy.3.Correlates with increased risk of diabetic cardiovascular disease.4.Potential biomarker for conditions like neonatal hypoxic-ischemic encephalopathy, liver injury, knee cartilage volume loss.