Low-dose tacrolimus has been proved to reverse the disease progression of PAH rats induced by mc and hypoxia, restore the normal function of pulmonary artery endothelial cells, and activate other functions of BMPR2 receptor signal transduction by removing FKBP12 from BMPR 1 type co-receptor (90).Based on B cell depletion therapy, patients who received rituximab (an anti-CD20 monoclonal antibody) showed a decrease in rheumatoid factor, IL-12 and IL-17 (37). This evidence concerns the gene IL17A and pulmonary arterial hypertension.