In this context, our study aimed to achieve two primary objectives: (1) in this context, our study aimed to achieve two primary objectives; (2) explore the potential links between IBD and clinical inflammatory markers, including interleukin-6 (Il-6), C-reactive protein (CRP), and tumor necrosis factor-α (TNF-α), employing univariate MR (UVMR). The gene discussed is TNF; the disease is irritable bowel syndrome.