TSC1 and Lennox-Gastaut syndrome: Pathogenic variants of CDKL5, KCNQ2, STXBP1, SCN1A, SCN2A, SCN8A, ALG13, GABRB3, TSC1, and TSC2 are considered the main causes of LGS, and corresponding gene-targeted therapies are being developed (3, 22).