LINC00858 and urinary bladder cancer: Subsequently, internalized exosomal LNMAT2 in human lymphoid endothelial cells upregulates prospero homology box 4 (PROX1) expression through epigenetic mechanisms, ultimately leading to lymphangiogenesis and lymphatic metastasis, thereby promoting bladder cancer progression (Tchurikov et al., 2015; Chen et al., 2019).