AKT1 and leukemia: Regulatory effects of Tregs on TIC phenotypes have been observed in leukemia through the secretion of IL10 and activation of PI3K/AKT signaling.[41] In solid tumors, Tregs have been reported to induce TIC phenotypes in breast cancer, but the underlying mechanisms remain unknown.[42] Whether Tregs play a potential role in regulating the TIC plasticity of LUAD should be further investigated in future studies.