COL18A1 and central nervous system cancer: In a xenograft model of glioma, systemic administration of MCSs loaded with Ad5F35 carrying IL-24 and/or endostatin and regulated by a Tet-on system (Ad5F35-Tet-on-E1B-Pro-Δ24-IL-24/endostatin) showed promise for glioma treatment while sparing normal cells [221].