During the prognostic analysis, we also found that PIAS3 showed an adverse role in PAAD (n = 261, HR > 1, p < 0.05), while PIAS2 and PIAS4 played a protective effect (n = 261, HR < 1, p < 0.05, Fig. 4L). This evidence concerns the gene PIAS4 and pancreatic adenocarcinoma.