PIAS4 acted as a protective prognostic factor in HNSC, KIRC or UCEC (HR < 1, p < 0.05, Fig. 2D), but was a detrimental prognostic factor in ACC, LAML, LGG, MESO (HR > 1, p < 0.05, Fig. 2D). This evidence concerns the gene PIAS4 and adrenal cortex carcinoma.