FOXP3 and neoplasm: However, hypofractionated radiotherapy also contributes to the recruitment of immunosuppressive cells such as FOXP3+ regulatory T cells (Tregs), tumor-associated neutrophils (TANs), tumor-associated macrophages (TAMS), and myeloid-derived suppressor cells (MDSCs) via a series of cytokines and chemokines, thereby inducing an immunosuppressive tumor microenvironment [9, 10].