To investigate the involvement of endothelial CXCR2 in DKD development, conditional knockout mice targeting Cxcr2 in glomerular endothelium were constructed (Cxcr2L/L,Cxcr2eCKO), The research results have demonstrated that knocking out CXCR2 in GECs could improve renal function in DKD mice. This evidence concerns the gene CXCR2 and diabetic kidney disease.