As shown in Fig. 7A, multiple classical signaling pathways of tumors were involved in the high-risk group, including the activation of oxidative phosphorylation, antigen processing and presentation, DNA replication and cell cycle and inhibition of focal adhesion, calcium signaling pathway, adherens junction, Wnt signaling pathway, pathways in cancer, MAPK pathway, PPAR pathway, TGF beta pathway, mTOR pathway, Toll-like receptor pathway, JAK-STAT pathway and P53 pathway. This evidence concerns the gene TP53 and cancer.