PELI1 and pachyonychia congenita: To confirm the expression of PELI1 at the transcriptional and translational levels in pancreatic cancer tissues and cells, we analyzed mRNA expression in normal, PC and paracancerous tissues from the TCGA database, coupled with the GTEx database, revealed a significantly elevated PELI1 mRNA expression in PC compared to normal or paracancerous tissues (Fig. S1A).