Once the above balance was broken, ROS would increase abnormally, so that the secretion of oxygen free radicals would increase, which would cause damage to the body, decrease the body’s defense ability, lack of antioxidant substances, and metabolic disorder, which would damage islet β cells, enhance IR, lack insulin secretion, increase blood sugar, and induce T2DM [9]. The gene discussed is INS; the disease is type 2 diabetes mellitus.