Approximately 70% of RCC are clear cell renal cell carcinoma (ccRCC), and other rare types of non-clear cell renal cell carcinoma include papillary renal cell carcinoma (pRCC), chromophobe renal cell carcinoma (chRCC), Xpll.2 Translocation/TFE3 Gene Fusions, and collecting duct carcinoma [2–3]. The gene discussed is TFE3; the disease is chromophobe renal cell carcinoma.