Correlation analysis between the level of intestinal inflammatory factors and the severity of HF showed that the levels of IL-1β, IL-4, IL-6 and TNF-α were positively correlated with NT-proBNP and the cardiac function score, which indicated that the increase in intestinal proinflammatory factors promoted the progression of HF and aggravated the severity of HF. The gene discussed is NPPB; the disease is hydrops fetalis.