Moreover, aberrant microglia activation and synaptic pruning is observed in neurodegenerative diseases such as Alzheimer’s disease (Hong et al, 2016), and ZBP1 also controls the NRLP3 inflammasome (Kuriakose et al, 2016), a key regulator of neuroinflammatory phenotypes in Alzheimer’s disease (Heneka et al, 2013). This evidence concerns the gene ZBP1 and early-onset autosomal dominant Alzheimer disease.