CSPG4 and neoplasm: To investigate the impact of pericyte-specific sGC inactivation during tumor development, we bred Gucy1b1flox/flox (designated as sGCCtr) mice with Cspg4-CreERT2 mice to generate Cspg4-CreERT2::Gucy1b1flox/flox (designated as sGC∆PC) mice, enabling the specific deletion of the catalytic β1 subunit of sGC in pericytes after administering five consecutive doses of Tamoxifen at the age of 4 weeks (Fig. 1A; Appendix Fig. S1A).