Considering the pivotal role of intercellular crosstalk between cancer cells and stromal cells in shaping the tumor microenvironment and driving tumor growth (Hinshaw and Shevde, 2019), we employed CellChat (Jin et al, 2021)—a tool that infers intercellular communication based on the expression of ligands, receptors and their cofactors in different cell populations—to examined the global alterations in cell–cell communications within LLC tumors following pericyte-specific sGC deletion (Fig. 2E). The gene discussed is SGCB; the disease is cancer.