Importantly, since FOXA1-altered prostate cancer cell lines [AR-dependent LAPC4 (class-2 frameshift) and AR-independent DU145 (FOXA1-low)] display a dependence on SEMA3C for proliferation, this suggests that cancer cells bearing FOXA1 alterations may exhibit a tumor vulnerability and growth pathway addiction to SEMA3C. Here, AR is linked to Familial prostate cancer.