Relationship between AKT3 and mutations related to MDS or MPN hematological disorders The MDS- or MPN-related mutations affect genes involved in different molecular aspects of gene expression including RNA splicing (SRSF2, U2AF1 and SF3B1), chromatin remodeling (ASXL1) and gene transcription (BCOR). The gene discussed is ASXL1; the disease is myelodysplastic syndrome.