AKT3 and acute myeloid leukemia: SRSF2, U2AF1, SRSF3, ASXL1 and BCOR mutations, and relations with MDS and MPN. In the 445 diagnosis samples of the Beat-AML cohort, a correlation between high levels of AKT3 expression and mutations of SRSF2 (n = 46), U2AF1 (n = 24), SRSF3 (n = 17), ASXL1 (n = 43) or BCOR (n = 23) is also observed (Fig. 6, left).