AKT2 and cancer: What could be the advantage for HSCs or leukemic blasts to express AKT3? As said in the introduction, a recent report indicates that unlike AKT1 and AKT2, the AKT3 kinase locates at the nuclear envelope, facing the cytosol, and its protein serine/threonine kinase activity appears constitutively activated in a panel of established cancer cells6.