ASXL1 and myeloproliferative neoplasm: Relationship between AKT3 and mutations related to MDS or MPN hematological disorders The MDS- or MPN-related mutations affect genes involved in different molecular aspects of gene expression including RNA splicing (SRSF2, U2AF1 and SF3B1), chromatin remodeling (ASXL1) and gene transcription (BCOR).