In colon cancer, Foxp3+ Tregs were classified into two subsets: CD38+Foxp3+ Tregs linked to negative prognosis, and CD38-Foxp3+ Tregs linked to positive survival.38 Given the distinct functions of each immune cell type, further research is crucial for accurately interpreting the immune results highlighted in this study. This evidence concerns the gene FOXP3 and malignant colon neoplasm.