Subgroup analysis showed higher confirmed ORR in patients with gastric cancer, TMB-high, Eastern Cooperative Oncology Group (ECOG) performance status (ps) of 0, or PD-L1 CPS ≥ 1, in contrast to individuals with gastroesophageal junction (GEJ) cancer, TMB-low, ECOG ps 1, or PD-L1 CPS < 1. This evidence concerns the gene CD274 and gastric cancer.