LEP and obesity due to melanocortin 4 receptor deficiency: Given that AN and obesity share some comorbidities, such as major depressive disorder63–65 as well as body dissatisfaction1,66,67 and regarding that metreleptin treatment in patients with AN and in one female with congenital leptin deficiency had beneficial effects on the mental traits32–34,68, the LEP variant might impact mental factors relevant for both, AN and obesity.