CCL5 and early-onset autosomal dominant Alzheimer disease: Elevated levels of CCL-5 have been linked to Alzheimer’s disease (AD) in patients.39 These pieces of evidence suggest that senescent SCMECs, also referred to as “zombie cells,” resulting from traumatic SCI, may secrete multiple pro-inflammatory SASP factors, creating an unfavorable microenvironment and leading to poor functional recovery after SCI.