CXCL8 and acute myeloid leukemia: Gene Ontology analysis, used to interpret the unbalanced processes biologically, revealed that interleukin pathways such as IL1, IL2, IL8 and IL10, MAPK, NFkB16–27 and migration-related pathways, which are known to be involved in AML progression, were associated with multiple unbalanced processes characterizing AML across all three datasets (Supplementary Note 1).