Gene Ontology analysis, used to interpret the unbalanced processes biologically, revealed that interleukin pathways such as IL1, IL2, IL8 and IL10, MAPK, NFkB16–27 and migration-related pathways, which are known to be involved in AML progression, were associated with multiple unbalanced processes characterizing AML across all three datasets (Supplementary Note 1). The gene discussed is IL2; the disease is acute myeloid leukemia.