Using genetic instruments for plasma proteome constituents has allowed us to identify hitherto unexplored potential risk factors for a number of the cancers, including: the cytokine like molecule, FAM3D, which plays a role in host defence against inflammation associated carcinogenesis with lung cancer33; the autophagy associated cytokine cardiotrophin-1 with lung (Probable), endometrial (Suggestive), prostate (Suggestive) and breast (Suggestive) cancer and the tumour progression associated antigen CD63 with endometrial cancer34,35. The gene discussed is CD63; the disease is neoplasm.