ISLR2 and renal cell carcinoma: We identified KDEL motif-containing protein 2 (KDELC2) and RCC, as well as Copine-1 (CPNE1) and Immunoglobulin superfamily containing leucine-rich repeat protein 2 (ISLR2) and breast cancer as having a high posterior probability of a shared variant (i.e. PPH4 > 0.8).