Our analysis also supports the reported relationship between higher levels of sex hormone-binding globulin with reduced endometrial cancer risk (Robust, ORSD = 0.81, 95% CI: 0.74–0.89, P = 9.00 × 10−6) and a relationship between testosterone with risk of endometrial (Probable, ORSD = 1.48, 95% CI: 1.12–1.96, P = 5.32 × 10−3) and breast (Probable, ORSD = 1.24, 95% CI: 1.09–1.42, P = 1.43 × 10−3) cancer14,15. Here, SHBG is linked to endometrial cancer.