However, higher levels of genetically predicted levels of fasting insulin (Probable, ORSD = 1.78, 95% CI: 1.25–2.52, P = 1.33 × 10−3) and insulin growth factor 1 (IGF-1) (Suggestive, ORSD = 1.06, 95% CI: 1.01–1.12, P = 3.26 × 10−2) and lower proinsulin (Probable, ORSD = 0.89, 95% CI: 0.82 - 0.96, P = 3.09 × 10−3) showed associations with CRC. This evidence concerns the gene INS and colorectal carcinoma.