This was followed by a report showing that the expression of NLRP3, CASP1, and IL1B in PBMCs from SLE patients was reduced compared with healthy donors (Yang et al, 2014), which is interesting given a proportion of SLE patients are known to have high type I IFN levels (Dall’Era et al, 2005). The gene discussed is NLRP3; the disease is systemic lupus erythematosus.