The voltage-gated KCNH1 (Kv10.1), the two-pore channel KCNK4 (TRAAK/TREK) and the small-conductance Ca2+-activated KCNN3 (SK3/KCa2.3) are all K+ channels whose increase in activities can lead to hypoplasia/aplasia of the distal phalanges, as well as lead to alterations in cranial-facial features and neuropathies [8,67–70]. Here, KCNK2 is linked to neuropathy.