GPR65 and myeloid sarcoma: In our experiments, the co-treatment of the human MO3.13 oligodendrocytes induced an overall downregulation of TDAG8 transcripts irrespective of the extracellular pH but most pronounced in low and high pH respectively implicating that the anti-inflammatory signalling through TDAG8 receptor may be directly affected by the cytokines mediating MS pathogenesis [46–50].