An additive interaction of hs-CRP and NLR on the risk of HF in males (RERI (OR): 0.67, 95% CI: 0.12–1.34; AP (OR): 0.14, 95% CI: 0.02–0.24; SI (OR): 1.22, 95% CI: 1.03–1.44). This evidence concerns the gene CRP and hydrops fetalis.