In addition to the possible mechanism proposed in this study for CGEtOAc, combined with sorafenib-induced apoptosis in cancer cells, which involves increased ROS accumulation and inhibition of PI3K/Akt/mTOR expression, the apoptotic effects resulting from the combination treatment of compounds found in C. gigantea extracts and anticancer agents may be attributed to several mechanisms. The gene discussed is AKT1; the disease is cancer.