Increased ROS production has been reported as a regulator of PI3K/Akt/mTOR expression, which results in cancer cell apoptosis, examples include kaemperol, a flavonoid found in Chinese herbs belonging to Zingiberaceae [23], piperlongumine isolated from Piper longum L. [24], isoorientin treatment [55], and ginsenoside Rk1 [37]. Here, AKT1 is linked to cancer.