MAP2K7 and choroidal neovascularization: As a result, it is hypothesized that the mechanism of action of MEK inhibitor-associated retinopathy is through disruption of the retinal pigment epithelium resulting in impaired function and subsequent exudation.20 Given this clinical knowledge, management should begin with observation and should not immediately involve therapies such as anti-VEGF injections unless choroidal neovascularization is detected.