Low OX40 TIL expression in tumor samples from NSCLC patients (n = 139) was associated with longer overall survival and better prognosis; however, the study did not specify the subtype of T lymphocytes (effector CD4 + /CD8 + T cells or CD4 + regulatory T cells) with OX40 expression [35]. This evidence concerns the gene TNFRSF4 and neoplasm.